Asus ESC4000-E10S

2U GPU server powered by dual-socket 3rd Gen Intel Xeon Scalable processors that supports up to 16 DIMM, four dual-slot GPU, 2 M.2, four NVMe (by SKU), total eleven PCIe 4.0 slots, one OCP 3.0 (by SKU) and ASUS ASMB10-iKVM.

Key Features Asus ESC4000-E10S

  • GPU-optimized design allows four dual-slot GPUs for AI workloads
  • Up to four NVMe and eight SATA/SAS drives on front panel to enable extensive storage and high-throughput performance
  • Up to eleven PCIe® 4.0 slots to enable higher bandwidth and improved data-transfer rates
  • Flexible air- solution to achieve lower power-usage effectiveness (PUE) and optimized TCO for data centers
  • Onboard ASUS ASMB10-iKVM for out-of-band management with ASPEED AST2600 controller
  • Integrated PFR FPGA as the platform Root-of-Trust solution for firmware resiliency
  • High power efficiency with redundant 2200W or 1600W 80 Plus® Platinum power supplies
  • Two hot-plug, hot-swap fans design for fully redundancy protection and thermal efficiency

Specification Asus ESC4000-E10S


Processor / System Bus
2 x Socket P+ (LGA 4189)
3rd Gen Intel® Xeon® Scalable Processors Family(235W)
Core Logic
Intel® PCH C621A
Total Slots :
16 (8-channel per CPU, 8 DIMM per CPU)
Capacity :
Maximum up to 2048GB RDIMM
Memory Type :
Memory Size :
128GB, 64GB, 32GB, 16GB
* Refer to support page for more information
Expansion Slots
– 4 x PCIe x16 slots (Gen4 x16 link, FH,FL) for dual-slot GPU cards or
  8 x PCIe x16 slots (Gen4 x8 link, FH,FL) for single-slot GPU cards*
– 2 x PCIe x16 slots (Gen4 x16 link, LP,HL)


– SKU-1:
1 x PCIe x8 slot (Gen4 x8 link, LP,HL)
– SKU-2:
1 x PCIe x8 slot (Gen4 x8 link, LP,HL) or
1 x OCP3.0 slot (Gen4 x16 link) by switching cables
– SKU-3:
1 x PCIe x8 slot (Gen4 x8 link, LP,HL) or
2 x M.2 sockets (Gen4 x4 link, up to 22110 module) by switching cables
Storage Controller :
Intel® PCH C621A
Optional kits Controller :
ASUS PIKE II 3008-8i 8-port SAS 12G HBA card
ASUS PIKE II 3108-8i 8-port SAS 12G RAID card
Drive Bays
8 x 2.5″ Hot-swap Storage Bays
(SKU-1 & SKU-2 Backplane Supports 6 x SATA/SAS + 2 x SATA/SAS/NVMe Devices**)
(SKU-3 Backplane Supports 8 x SATA/SAS/NVMe Devices)
1 x M.2 socket (Gen3 x4 link or SATA mode, up to 2280 on-motherboard)
2 x 1GbE LAN ports (RJ45, Intel I350-AM2)
Front I/O Ports
4 x USB 3.2 Gen1 ports
Rear I/O Ports
2 x USB 3.2 Gen1 ports
1 x VGA port
2 x 1GbE LAN ports (RJ45)
1 x Management port (RJ45)

Front :
1 x Power Button/LED
1 x Location Button/LED
1 x Message LED
1 x HDD Access LED

Rear :
1 x Power Button/LED
1 x Location LED
1 x Message LED
1 x HDD Access LED

Management Solution
ASUS Control Center
ASUS ASMB11-iKVM (on-board)
Regulatory Compliance
CB, CE, RCM, FCC(Class A)
800 x 440 x 88.9mm
Form Factor
Net Weight: 34 Kg.
Gross Weight: 44 Kg.
Power Supply

1+1 Redundant 1600W 80 PLUS Platinum Power Supply C-14 power inlet
Rating: 100-127Vac/200-240Vac,12.9A/9.5A,50-60Hz

1+1 Redundant 2200W 80 PLUS TITANIUM Power Supply C-20 power inlet
Rating: 100-127Vac/200-240Vac,14A/12.6A,47-63Hz


Operating temperature: 10°C – 35°C
Non operating temperature: -40°C – 70°C
Non operating humidity: 20% – 90% (Non condensing)


*We also provide special GPU riser cards (with PCIe-switch) could support 8 single-slot GPU cards (x16 link for each). If customers need the customization, please contact ASUS sales representative for detail.

**Default supports 2 x NVMe SSD. If users need to install 4 x NVMe SSD, please remove Slimline cables from the PCIe riser board , and re-connect the cables to the backplane.

World Records Leadership

ASUS holds the most amount of records in dual-socket (2P) and single-socket (1P) on SPEC CPU 2017 benchmark and dominate the computing performance. These top performance results provide a useful insight into compute-intensive workloads on different computer systems, enabling our customers to reduce complexity, tackle challenging workloads and accelerate system validations.

ASUS servers feature Performance Boost technology to achieve the best server performance and agility by tuning servers to match the requirements of workloads, letting you gain greater control of your server environment. This technology improves workload throughput by maximizing processor frequency and boost power, ideal for timesensitive applications such as financial services or data center operations.

Core Optimizer

Maximizes the processor frequency in multi-core operations, avoiding frequency shifting for reduced latency.

Engine Boost

Automatic power acceleration with an innovative voltage design to increase server overall performance.

Workload Presets

Preconfigured BIOS server profiles based on workloads and benchmarks for improved performance and efficiency.

ASUS select servers achieved most power efficiency positions on the SPEC Power benchmark for energy efficiency and demonstrate to customers how they can achieve faster deployments and higher energy efficiency for their IT infrastructure.

ASUS Power Balancer

Adjust overall loading automatically based on real-time monitoring to decrease overall power consumption for Improved efficiency and cost/performance optimization.

Thermal Radar 2.0

Features intelligent fan-curve adjustments to fit the real-time server usage patterns and lower fan power consumption.

Server-management Solution

Remote server management

ASUS ASMB11-iKVM is the latest server-management solution from ASUS, built upon the ASPEED 2600 chipset running on the latest AMI MegaRAC SP-X. The module provides various interfaces to enable out-of-band server management through WebGUI, Intelligent Platform Management Interface (IPMI) and Redfish® API.

Streamline IT operations via a single dashboard

ASUS Control Center (ACC) is remote IT management software designed for monitoring your hardware and software IT assets and inventory status and enabling seamless remote BIOS configurations and updates, efficient IT diagnostics and troubleshooting and enhanced security with Hotfix updates, allowing easier server management for any IT infrastructure.

Enhanced Security

Hardware Root-of-Trust Solution

Detect, recover, boot and protect

ASUS servers integrate PFR FPGA as the platform Root-of-Trust solution for firmware resiliency to prevent from hackers from gaining access to infrastructure. ASUS security solutions are fully compliant with the 2018 National Institute of Standards and Technology (NIST) SP 800 193 specification.

* Platform Firmware Resilience (PFR) module must be specified at time of purchase and is factory-fitted. It is not for sale separately.

Trusted Platform Module 2.0

ASUS servers also include support Trusted Platform Module 2.0 (TPM 2.0) to secure hardware through integrated cryptographic keys and offer regular firmware update for vulnerabilities.

  • Products certified by the Federal Communications Commission and Industry Canada will be distributed in the United States and Canada. Please visit the ASUS USA and ASUS Canada websites for information about locally available products.
  • All specifications are subject to change without notice. Please check with your supplier for exact offers. Products may not be available in all markets.
  • Specifications and features vary by model, and all images are illustrative. Please refer to specification pages for full details.
  • PCB color and bundled software versions are subject to change without notice.
  • Brand and product names mentioned are trademarks of their respective companies.
  • The terms HDMI and HDMI High-Definition Multimedia Interface, HDMI trade dress and the HDMI Logos are trademarks or registered trademarks of HDMI Licensing Administrator, Inc. in the United States and other countries.
  • The information contained is general testing result for reference. Please consult local sales representative for more information on specific supported CPU list on each system.
  • * Optional means “built for order”.

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